Journal
BIOMATERIALS
Volume 151, Issue -, Pages 66-77Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2017.10.018
Keywords
Hybrid nanocomposite; Tissue adhesive; ROS scavenging; Microenvironment modulation; Regenerative healing
Funding
- National Key Research and Development Program of China [2016YFA0203600]
- National Natural Science Foundation of China [51503180, 5161101036, 51703195, 81620108028]
- Thousand Talents Program [588020*G81501/048]
- Fundamental Research Funds for the Central Universities [520002*172210161]
- Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents
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Restoration of tissue integrity and tissue function of wounded skin are both essential for wound repair and regeneration, while synergistic promotion of the two remains elusive. Since elevated reactive oxygen species (ROS) production in the injured site has been implicated in triggering a set of deleterious effects such as cellular senescence, fibrotic scarring, and inflammation, it is speculated that alleviating oxidative stress in the microenvironment of injured site would be beneficial to promote regenerative wound healing. In this study, a highly versatile ROS-scavenging tissue adhesive nanocomposite is synthesized by immobilizing ultrasmall ceria nanocrystals onto the surface of uniform mesoporous silica nanoparticles (MSN). The ceria nanocrystals decorated MSN (MSN-Ceria) not only has strong tissue adhesion strength, but also significantly restricts ROS exacerbation mediated deleterious effects, which efficiently accelerates the wound healing process, and more importantly, the wound area exhibits an unexpected regenerative healing characteristic featured by marked skin appendage morphogenesis and limited scar formation. This strategy can also be adapted to other wound repair where both ROS-scavenging activity and tissue adhesive ability matter. (C) 2017 Elsevier Ltd. All rights reserved.
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