Journal
BIOMATERIALS
Volume 161, Issue -, Pages 1-10Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2018.01.026
Keywords
Polypyrrole; Photothermal therapy; Biomimetic mineralization; MRI
Funding
- National Natural Science Foundation of China [51573039, 51273058, 81372712]
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Theranostic agents with perfect properties are needed urgently for the development of imaging guided photothermal therapy (PTT). In this work, Gd-integrated polypyrrole nanotheranostic agent (PPy@BSA-Gd) was successfully built through selecting bovine serum albumin (BSA) as both stabilizers for polymerization and biomimetic mineralization in one pot. The obtained PPy@BSA-Gd possessed high stability and excellent photothermal property. Besides, relevant cellular assays indicated that PPy@BSA-Gd had fantastic cytocompatibility which could be further internalized by cancer cells. Due to their high longitudinal relaxivity value (r(1) = 10.203 mM(-1) s(-1)), PPy@BSA-Gd could serve as considerable probe for T-1-weighted magnetic resonance imaging (MRI). After tail vein injection of PPy@BSA-Gd, the MR signal of tumor section.exhibited a time-dependent increase, indicating effective tumor accumulation of PPy@BSA-Gd. Notably, when exposed to 808 nm laser, the tumor growth of PPy@BSA-Gd treated mice could be inhibited by photothermal ablation successfully. All the results demonstrated the well-designed PPy@BSA-Gd have the potential for tumor diagnose and photothermal therapy. (C) 2018 Elsevier Ltd. All rights reserved.
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