Journal
BIOMATERIALS
Volume 159, Issue -, Pages 25-36Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2018.01.007
Keywords
Cancer cell membrane; Carrier-free; NIR-responsive; Self-reorganization; Chemo-/photothermal therapy
Funding
- National Natural Science Foundation of China [51703161]
- National Natural Science Funds for Distinguished Young Scholar [51325305]
- Tianjin Municipal Natural Science Foundation [17JCQNJC02900]
- National Key Research and Development Program [2016YFC1101301]
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Cell membrane-camouflaged nanoparticles for cancer therapy have received a burgeoning interest over the past years. However, the low drug loading and intratumoral release efficiency, and lack of precise targeting remains a big challenge; in addition, foreign carriers used may pose an expected burden in the course of metabolism. In this study, we designed and fabricated a novel NIR-responsive highly targeted carrier-free nanosystem by coating the exactly identical source of cracked cancer cell membranes (CCCMs) specifically derived from the homologous tumors onto the surface of the co-assembly nano particles of doxorubicin (DOX) and FDA-approved photothermal agent, indocyanine green (ICG). The nanosystems exhibited a high drug loading capacity (89.8%), cancer cell self-recognized ability and immune escape function. Further, the nanodrugs could be efficiently released for the membrane disturbance triggered by photothermal effect of ICG under NIR irradiation. The tumor-bearing mice model demonstrated that the self-carried DOX NPs@ICG@CCCM nanoparticles possessed a strong synergistic chemo-/photothermal therapeutic efficacy against tumors in vivo. The present strategy could be developed as a universal approach for designing and constructing carrier-free theranostic nanovehicles by intentionally selecting specific cancer cell membrane and the inner loading cargoes. (C) 2018 Elsevier Ltd. All rights reserved.
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