Journal
BIOMATERIALS
Volume 169, Issue -, Pages 35-44Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2018.03.041
Keywords
Molecule probe; NIR II bioimaging; Renal clearance; Tiny tumor diagnosis; X-ray bioimaging
Funding
- National Natural Science Foundation of China [21671064]
- Science and Technology Planning Project of Hunan Province [2017RS3031]
- Hunan Provincial Innovation Foundation for Postgraduate [CX2017B223]
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In vivo optical imaging by using a new imaging window located at short-wavelength infrared region (1000-1700 nm, named as NIR II) presents an unprecedented improvement in imaging sensitivity and spatial resolution over the traditional visible and near-infrared light. However, the most developed NIR II-emitters are hardly excreted from live animals, leading to unknown long-term toxicity concerns, which hinder the widespread applications of this advanced imaging technology. Here, we developed a new generation molecular NIR II-emitting probe based on Nd-diethylene triamine pentacetate acid (DTPA) complex. The designed molecular Nd-DTPA probe with bright narrow band emission at 1330 nm is successfully used for highly sensitive in vivo NIR II bioimaging with rapid renal excretion, high biocompatibility and optical-guided tiny tumor (down to similar to 3 mm) detection for the first time. Moreover, the Nd-DPTA complex also holds great promise as an X-ray contrast agent. These findings open up the possibility for designing a new generation of multi-modal small molecular probe for early tumor diagnosis and favor the clinic translation of the advanced NIR II imaging method. (C) 2018 Elsevier Ltd. All rights reserved.
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