Journal
BIOMATERIALS
Volume 173, Issue -, Pages 71-86Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2018.05.006
Keywords
Degradable vascular graft; Biodegradable; In situ tissue engineering; Host remodeling
Funding
- National Science Foundation [1247842]
- National Institutes of Health [2T32-HL076124, R01HL089658, R01HL128602]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL089658, T32HL076124, R01HL128602] Funding Source: NIH RePORTER
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Traditional tissue-engineered vascular grafts have yet to gain wide clinical use. The difficulty of scaling production of these cell- or biologic-based products has hindered commercialization. In situ tissue engineering bypasses such logistical challenges by using acellular resorbable scaffolds. Upon implant, the scaffolds become remodeled by host cells. This review describes the scientific and translational advantages of acellular, synthetic vascular grafts. It surveys in vivo results obtained with acellular synthetics over their fifty years of technological development. Finally, it discusses emerging principles, highlights strategic considerations for designers, and identifies questions needing additional research. (C) 2018 Elsevier Ltd. All rights reserved.
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