Journal
BIOMARKERS IN MEDICINE
Volume 12, Issue 7, Pages 759-769Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2017-0443
Keywords
HNSCC; immune suppression; phospho-stathmin 1 (serine38); poor survival; p-STAT3; Stathmin 1
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Funding
- National Natural Science Foundation of China [81472528, 81672668, 81472529, 81672667]
- Fundamental Research Funds for the Central Universities of China [2042017kf0171]
- Hubei Province Natural Science Funds for Distinguished Young Scholar [2017CFA062]
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Aim: Immunohistochemistry was used to detect the expression of Stathmin 1 and Serine 38 phospho-Stathmin 1 (p-Stathmin 1(S38)) in head and neck squamous cell carcinoma (HNSCC) and research its correlation with clinical parameters, survival and expression of immune checkpoint molecules. Results: Stathmin 1 and p-Stathmin 1(S38) overexpression in primary HNSCC is associated with poor overall survival. Stathmin 1 expression is related to tumor size, category and lymph node status. Stathmin 1 expression correlates with PD-L1, TIM3, VISTA, B7-H3, B7-H4, LAG-3 and p-STAT3 expression in HNSCC. P-Stathmin 1(S38) expression correlates with PD-L1, VISTA, B7-H4, LAG-3 and p-STAT3 in HNSCC. Conclusion: We found expression of Stathmin 1 and p-Stathmin 1(S38) indicates poor survival in HNSCC and may be associated with immune suppression.
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