Journal
BIOLOGICAL TRACE ELEMENT RESEARCH
Volume 186, Issue 2, Pages 379-383Publisher
HUMANA PRESS INC
DOI: 10.1007/s12011-018-1332-z
Keywords
Sarcopenia; Iron accumulation; Skeletal muscle; Ferritin
Funding
- Jiangsu provincial key research and development program [BE2016720]
- Jiangsu provincial maternal and child health program [F201506]
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Sarcopenia has a high incidence among the elderly, with significant negative effects on the quality of life. The pathogenesis of sarcopenia is complex, and many factors are involved in its development and progression. Sarcopenia might be associated with iron accumulation given that (1) age-related iron accumulation was found in the skeletal muscle, (2) excess iron could cause skeletal muscle damage or atrophy, and (3) patients with sarcopenia showed higher levels of serum ferritin. Understanding the etiology and pathogenesis of sarcopenia would help to develop new treatment and preventive methods, thereby improving the quality of life of the elderly patients.
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