Journal
BIOLOGICAL REVIEWS
Volume 93, Issue 3, Pages 1339-1362Publisher
WILEY
DOI: 10.1111/brv.12398
Keywords
axon regeneration; integrin; kindlin; receptor activation state; selective polarised transport; traumatic injury of the nervous system
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Funding
- International Spinal Research Trust [NRB110]
- Medical Research Council [G1000864]
- ERA-NET NEURON grant AxonRepair [013-16-002]
- Hersenstichting Nederland, NWO
- Laboratory for Regeneration of Sensorimotor Systems at the Netherlands Institute for Neuroscience
- International Spinal Research Trust [NRB110] Funding Source: researchfish
- Medical Research Council [G1000864, MR/R004544/1, MR/R004463/1] Funding Source: researchfish
- BBSRC [BB/N008189/1] Funding Source: UKRI
- MRC [MR/R004544/1, G1000864, MR/R004463/1] Funding Source: UKRI
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Integrins are cell surface receptors that form the link between extracellular matrix molecules of the cell environment and internal cell signalling and the cytoskeleton. They are involved in several processes, e.g. adhesion and migration during development and repair. This review focuses on the role of integrins in axonal regeneration. Integrins participate in spontaneous axonal regeneration in the peripheral nervous system through binding to various ligands that either inhibit or enhance their activation and signalling. Integrin biology is more complex in the central nervous system. Integrins receptors are transported into growing axons during development, but selective polarised transport of integrins limits the regenerative response in adult neurons. Manipulation of integrins and related molecules to control their activation state and localisation within axons is a promising route towards stimulating effective regeneration in the central nervous system.
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