Journal
BIOLOGICAL PSYCHIATRY
Volume 83, Issue 10, Pages 800-809Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2017.10.006
Keywords
Amygdala; Extinction; Fear learning; Interneuron; Neuronal circuits; Plasticity
Categories
Funding
- Novartis Research Foundation
- European Research Council under the European Union's Horizon research and innovation programme [669582]
- Swiss National Science Foundation
- National Center of Competences in Research: SYNAPSY - The Synaptic Bases of Mental Diseases (Swiss National Science Foundation)
- EMBO
- Swiss National Science Foundation (Ambizione)
- Brain & Behavior Research Foundation
- European Research Council (ERC) [669582] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
Associative memory formation is essential for an animal's survival by ensuring adaptive behavioral responses in an ever-changing environment. This is particularly important under conditions of immediate threats such as in fear learning. One of the key brain regions involved in associative fear learning is the amygdala. The basolateral amygdala is the main entry site for sensory information to the amygdala complex, and local plasticity in excitatory basolateral amygdala principal neurons is considered to be crucial for learning of conditioned fear responses. However, activity and plasticity of excitatory circuits are tightly controlled by local inhibitory interneurons in a spatially and temporally defined manner. In this review, we provide an updated view on how distinct interneuron subtypes in the basolateral amygdala contribute to the acquisition and extinction of conditioned fear memories.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available