Cul-catalyzed oxidative cross coupling of oximes with tetrahydrofuran: a direct access to Ο-tetrahydrofuran-2-yl oxime ethers

An efficient copper(I)-catalyzed oxidative tetrahydrofuranylation of oximes has been developed. This reaction shows good functional group tolerance and various substituted ketoximes and aldoximes coupled smoothly with THF to give the corresponding O-tetrahydrofuran-2-yl oxime ethers in high yields.