Journal
BIOLOGICAL CHEMISTRY
Volume 399, Issue 7, Pages 623-635Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2018-0141
Keywords
local translation; neurodegenerative diseases; neuronal RNA granule; RNA granule; RNA transport; RNP assembly and remodeling
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Funding
- ANR (RNAGRIMP research grant)
- ANR ('Investments for the Future' LABEX SIGNALIFE program) [ANR-11-LABX-0028-01]
- Canceropole PACA (Emergence grant)
- JPND program (FlySMALS grant)
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Neuronal cells rely on macro-and micro-cellular compartmentalization to rapidly process information, and respond locally to external stimuli. Such a cellular organization is achieved via the assembly of neuronal ribonucleoprotein (RNP) granules, dynamic membrane-less organelles enriched in RNAs and associated regulatory proteins. In this review, we discuss how these high-order structures transport mRNAs to dendrites and axons, and how they contribute to the spatio-temporal regulation of localized mRNA translation. We also highlight how recent biophysical studies have shed light on the mechanisms underlying neuronal RNP granule dynamic assembly, remodeling and maturation, in both physiological and pathological contexts.
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