Journal
BIOLOGICAL CHEMISTRY
Volume 399, Issue 4, Pages 305-319Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/hsz-2017-0250
Keywords
Alzheimer's disease; biomechanistics; epilepsy; Huntington's disease; neurological disorders; oxidative stress; parkinsonism, pathogenesis
Categories
Ask authors/readers for more resources
Neurological diseases like Alzheimer's disease, epilepsy, parkinsonism, depression, Huntington's disease and amyotrophic lateral sclerosis prevailing globally are considered to be deeply influenced by oxidative stress-based changes in the biochemical settings of the organs. The excess oxygen concentration triggers the production of reactive oxygen species, and even the intrinsic antioxidant enzyme system, i.e. SOD, CAT and GSHPx, fails to manage their levels and keep them under desirable limits. This consequently leads to oxidation of protein, lipids and nucleic acids in the brain resulting in apoptosis, proteopathy, proteasomes and mitochondrion dysfunction, glial cell activation as well as neuroinflammation. The present exploration deals with the evidence-based mechanism of oxidative stress towards development of key neurological diseases along with the involved biomechanistics and biomaterials.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available