Journal
BIOFOULING
Volume 34, Issue 2, Pages 212-225Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/08927014.2018.1425402
Keywords
Biofilm; mycology; pathogenesis; Candida albicans; Lactobacillus
Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/26820-4, 2013/25181-8, 2015/09770-9]
- Brown/Brazil Initiative
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This study isolated Lactobacillus strains from caries-free subjects and evaluated the inhibitory effects directly on three strains of C. albicans, two clinical strains and one reference strain. Thirty Lactobacillus strains were isolated and evaluated for antimicrobial activity against in vitro C. albicans biofilms. L. paracasei 28.4, L. rhamnosus 5.2 and L. fermentum 20.4 isolates exhibited the most significant inhibitory activity against C. albicans. Co-incubation between these microorganisms resulted in deterrence of biofilm development and retardation of hyphal formation. The hindrance of biofilm development was characterized by the downregulated expression of C. albicans biofilm-specific genes (ALS3, HWP1, EFG1 and CPH1). L. paracasei 28.4, L. rhamnosus 5.2 and L. fermentum 20.4 demonstrated the ability to exert antifungal activity through the inhibition of C. albicans biofilms.
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