Journal
BIOELECTROCHEMISTRY
Volume 122, Issue -, Pages 221-226Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.bioelechem.2017.11.001
Keywords
Magnetic bead; Lab-on-a-Chip (LOC); beta-hCG; Antibody; Immunoassay
Funding
- Kwangwoon Research Grant of 2017
- i-sens Inc. in Korea
- Technological Innovation R&D program of the SMBA [S2498668]
- Basic Science Research Program through the National Research Foundation of Korea (NRF), - Ministry of Education [NRF-2015R1D1A1A01060369]
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In this work, a Lab-on-a-Chip (LOC) platform is used to electromagnetically actuate magnetic bead chains for an enhanced immunoassay. Custom-made electromagnets generate a magnetic field to form, rotate, lift and lower the magnetic bead chains (MBCs). The cost-effective, disposable LOC platform was made with a polymer substrate and an on-chip electrochemical sensor patterned via the screen-printing process. The movement of the MBC5 is controlled to improve the electrochemical signal up to 230% when detecting beta-type human chorionic gonadotropin (beta-hCG). Thus, the proposed on-chip MBC-based immunoassay is applicable for rapid, qualitative electrochemical point-of-care (POC) analysis. (C) 2017 Elsevier B.V. All rights reserved.
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