Journal
BIOCONJUGATE CHEMISTRY
Volume 29, Issue 3, Pages 624-634Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.7b00669
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Funding
- National Institutes of Health [R21AI133372]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI133372] Funding Source: NIH RePORTER
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Cell membrane engineering, including live cell membrane bioconjugation and cell membrane-derived nanomaterials is a highly promising strategy to modulate immune responses for treating diseases. Many cell membrane engineering methods have potential for translation for human clinical use in the near future. In this Topical Review, we summarize the cell membrane conjugation strategies that have been investigated for cancer immunotherapy, the prevention of immune rejection to donor cells and tissues, and the induction of antigen-specific tolerance in autoimmune diseases. Additionally, cell membrane-derived or membrane-coated nanomaterials are an emerging class of nanomaterials that is attracting significant attention in the field of nanomedicine. Some of these nanomaterials have been employed to elicit immune responses against cancer, toxins, and bacteria, although their application in establishing immune tolerance has not been explored. In addition to discussing potential problems, we provide our perspectives for promising future directions.
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