Journal
BIOCONJUGATE CHEMISTRY
Volume 29, Issue 2, Pages 467-472Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.bioconjchem.7b00790
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Funding
- National Key Basic Research Program of China [2014CB744503]
- National Natural Science Foundation of China [81471707, 21271030]
- Scientific Research Foundation of State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics [2016ZY002]
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We report a novel thiol selective radioiodination method based on strain-release reaction. A new heterobifunctional radioiodination agent which has very good thiol selectivity and excellent stability with high radiolabeling yield was synthesized, characterized, and applied successfully for thiol-contained peptide labeling.
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