Journal
BIOCHIP JOURNAL
Volume 12, Issue 1, Pages 1-10Publisher
KOREAN BIOCHIP SOCIETY-KBCS
DOI: 10.1007/s13206-017-2101-3
Keywords
Paper; Biosensor; Biochip; Plasmonics; Nanofabrication
Funding
- National Research Foundation of Korea grant - the Korea government [2017016315, 2016013061]
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Biomolecules in human body serve as biomarker for diagnosis of diseases, and paper-based biochips have become of much interest for development of biomolecule sensing. Cellulose micro-/nanofiber matrices consisting of paper allow not only capillary-driven flow without external pumping owing to abundant micro-/nanopores but also three-dimensional (3D) hierarchical micro-/nanostructures as 3D templates for microfluidic bioassays. Besides, colloidal and thermal evaporated metal nanoparticles on cellulose fibers offer huge opportunities in nanoplasmonic biosensing. Here, we review paper-based biochips including microfluidic paper-based assays and nanoplasmonic biosensors and further discuss micro-/nanofabrication of paper-based biochips and their applications in biomolecule detection.
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