Journal
BIOCHIMIE
Volume 159, Issue -, Pages 49-54Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2018.07.010
Keywords
Aging; Autophagy; Degeneration; Fatty acids; Inflammation; Macula; Oxidative stress
Categories
Funding
- European Commission: EC H2020 MSCA - ITN [722717]
- Academy of Finland [296840]
- Finnish Eye Foundation
- Sigrid Juselius Foundation
- Paivikki and Sakari Sohlberg Foundation
- Business of Finland
- Kuopio University Hospital VTR [5503757]
- University of Eastern Finland
- Academy of Finland (AKA) [296840, 296840] Funding Source: Academy of Finland (AKA)
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Retinal pigment epithelium (RPE) damage is a primary sign in the development of age-related macular degeneration (AMD) the leading cause of blindness in western countries. RPE cells are exposed to chronic oxidative stress due to constant light exposure, active fatty acid metabolism and high oxygen consumption. RPE cells phagocytosize lipid rich photoreceptor outer segment (POS) which is regulated by circadian rhytmn. Docosahexaenoic acid is present in high quantity in POS and increases oxidative stress, while its metabolites have cytoprotective effects in RPE. During RPE aging, reactive oxygen species and oxidized lipoproteins are considered to be major causes of disturbed autophagy clearance that lead to chronic innate immunity response involved in NOD-Like, Toll-Like, Advanced Glycation End product Receptors (NLRP, TLR, RAGE, respectively), pentraxins and complement systems. We discuss role of fatty acids and lipoproteins in the degeneration of RPE and development of AMD. (C) 2018 Published by Elsevier B.V.
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