Journal
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1870, Issue 1, Pages 23-31Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbcan.2018.06.003
Keywords
Cancer; Hypoxia-inducible factors; Genetics; Mouse models; Lipid metabolism; Therapy
Categories
Funding
- National Institutes of Health [T32HD083185, F31CA206381, P01CA104838]
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Clear cell renal cell carcinoma (ccRCC) is a malignancy characterized by deregulated hypoxia-inducible factor signaling, mutation of several key chromatin modifying enzymes, and numerous alterations in cellular metabolism. Pre-clinical studies have historically been limited to cell culture models, however, the identification of critical tumor suppressors and oncogenes from large-scale patient sequencing data has led to several new genetically engineered mouse models with phenotypes reminiscent of ccRCC. In this review, we summarize recent literature on these topics and discuss how they inform targeted therapeutic approaches for the treatment of ccRCC.
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