Journal
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1869, Issue 2, Pages 97-102Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbcan.2017.12.006
Keywords
Hepatocellular carcinoma; Obesity; Nervous system; Circadian rhythm; Immune response
Categories
Funding
- Major National Scientific Research Projects [2015CB943102]
- National Natural Science Foundation of China [31572365]
- Key Scitech innovation team of Shaanxi province [2017KCT-24]
- Fundamental Research Funds for the Central Universities [2452017084]
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Hepatocellular carcinoma (HCC) is the commonest primary liver cancer and the second leading cause of cancer death worldwide. Obesity is rapidly becoming pandemic and associated with increased carcinogenesis. In this review, we describe the obesity-related factors that influence the development of HCC. We provide evidence of strong links between neural regulation, endocrine and HCC in obesity. We discuss recent advances in our understanding of how adipose tissue alters hepatic metabolism and immune response in HCC development through inter-organ communication. Taken together, our review aims to provides a concise and up-to date summary about the connection between obesity and HCC, with emphasis on the opportunities for effective strategies in preventing the development of HCC in obese individuals.
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