Journal
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1870, Issue 1, Pages 2-14Publisher
ELSEVIER
DOI: 10.1016/j.bbcan.2018.04.009
Keywords
Metabolomics; Cancer metabolism; Metabolic subtypes; Systems biology; Isotope tracing; And metabolite imaging
Categories
Funding
- NCI [R35 CA220449, P50 CA175754]
- Cancer Prevention and Research Institute of Texas [RP160089]
- Howard Hughes Medical Institute
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Reprogrammed metabolism supports tumor growth and provides a potential source of therapeutic targets and disease biomarkers. Mass spectrometry-based metabolomics has emerged as a broadly informative technique for profiling metabolic features associated with specific oncogenotypes, disease progression, therapeutic liabilities and other clinically relevant aspects of tumor biology. In this review, we introduce the applications of metabolomics to study deregulated metabolism and metabolic vulnerabilities in cancer. We provide examples of studies that used metabolomics to discover novel metabolic regulatory mechanisms, including processes that link metabolic alterations with gene expression, protein function, and other aspects of systems biology. Finally, we discuss emerging applications of metabolomics for in vivo isotope tracing and metabolite imaging, both of which hold promise to advance our understanding of the role of metabolic reprogramming in cancer.
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