Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1865, Issue 11, Pages 1687-1697Publisher
ELSEVIER
DOI: 10.1016/j.bbamcr.2018.07.011
Keywords
Heart failure; Diabetes; Duchenne muscular dystrophy; PTSD; Sudden cardiac death; CPVT; Arrhythmias; Alzheimer's disease; Sarcopenia
Categories
Funding
- NHLBI [R01-HL061503, R01-HL140934, R01-AR070194]
- NCI [R01-HL061503, R01-HL140934, R01-AR070194]
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Regulation of intracellular calcium (Ca2+) is critical in all cell types. The ryanodine receptor (RyR), an intracellular Ca2+ release channel located on the sarco/endoplasmic reticulum (SR/ER), releases Ca2+ from intracellular stores to activate critical functions including muscle contraction and neurotransmitter release. Dysfunctional RyR-mediated Ca2+ handling has been implicated in the pathogenesis of inherited and non-inherited conditions including heart failure, cardiac arrhythmias, skeletal myopathies, diabetes, and neurode-generative diseases. Here we have reviewed the evidence linking human disorders to RyR dysfunction and describe novel approaches to RyR-targeted therapeutics.
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