Journal
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
Volume 1860, Issue 4, Pages 868-877Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamem.2017.08.011
Keywords
ABC transporters; Pathogenesis; Metal transport; Peptide transport; Amino acid transport; Emerging therapy
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Funding
- NIAID NIH HHS [R01 AI139519] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008382] Funding Source: Medline
- National Research Foundation of Korea [2016R1A6A3A03008451] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The uptake of nutrients, including metals, amino acids and peptides are required for many biological processes. Pathogenic bacteria scavenge these essential nutrients from microenvironments to survive within the host. Pathogens must utilize a myriad of mechanisms to acquire these essential nutrients from the host while mediating the effects of toxicity. Bacteria utilize several transport proteins, including ATP-binding cassette (ABC) transporters to import and expel substrates. ABC transporters, conserved across all organisms, are powered by the energy from ATP to move substrates across cellular membranes. In this review, we will focus on nutrient uptake, the role of ABC importers at the host pathogen interface, and explore emerging therapies to combat pathogenesis. This article is part of a Special Issue entitled: Beyond the Structure-Function Horizon of Membrane Proteins edited by Ute Hellmich, Rupak Doshi and Benjamin Mcllwain.
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