Journal
BIOCHEMISTRY
Volume 57, Issue 24, Pages 3309-3325Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biochem.8b00239
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Funding
- National Institutes of Health [R01 GM093903]
- National Science Foundation [CHE-1309148]
- National Natural Science Foundation of China [31670030]
- China Scholarship Council
- Warren-McLoed fellowship from the Boston University Marine Program
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1309148] Funding Source: National Science Foundation
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As one of the most abundant elements on earth, sulfur is part of many small molecular metabolites and is key to their biological activities. Over the past few decades, some general strategies have been discovered for the incorporation of sulfur into natural products. In this review, we summarize recent efforts in elucidating the biosynthetic details for two sulfur-containing metabolites, ergothioneine and ovothiol. Their biosyntheses involve an unprecedented trans-sulfur strategy, a combination of a mononuclear non-heme iron enzyme-catalyzed oxidative C-S bond formation reaction and a PLP enzyme-mediated C-S lyase reaction.
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