Related references
Note: Only part of the references are listed.In vivo evidence supporting a metastasis suppressor role for Stard13 (Dlc2) in ErbB2 (Neu) oncogene induced mouse mammary tumors
Pratima Basak et al.
GENES CHROMOSOMES & CANCER (2018)
Truncated isoform Vav3.1 is highly expressed in ovarian cancer stem cells and clinically relevant in predicting prognosis and platinum-response
Daniel Reimer et al.
INTERNATIONAL JOURNAL OF CANCER (2018)
Activation of RHOA-VAV1 signaling in angioimmunoblastic T-cell lymphoma
M. Fujisawa et al.
LEUKEMIA (2018)
Loss of RhoA promotes skin tumor formation and invasion by upregulation of RhoB
A. Garcia-Mariscal et al.
ONCOGENE (2018)
Genetic Predictors of Response to Systemic Therapy in Esophagogastric Cancer
Yelena Y. Janjigian et al.
CANCER DISCOVERY (2018)
RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis
Jose R. Cortes et al.
CANCER CELL (2018)
Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer
Rona Yaeger et al.
CANCER CELL (2018)
Novel p21-Activated Kinase 4 (PAK4) Allosteric Modulators Overcome Drug Resistance and Stemness in Pancreatic Ductal Adenocarcinoma
Amro Aboukameel et al.
MOLECULAR CANCER THERAPEUTICS (2017)
ROCK2/rasHa co-operation induces malignant conversion via p53 loss, elevated NF-κB and tenascin C-associated rigidity, but p21 inhibits ROCK2/NF-κB-mediated progression
S. F. Masre et al.
ONCOGENE (2017)
Rho GTPases: Anti- or pro-neoplastic targets?
I. Zandvakili et al.
ONCOGENE (2017)
Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers
Soo Young Cho et al.
GASTROENTEROLOGY (2017)
Mutations in 5-methylcytosine oxidase TET2 and RhoA cooperatively disrupt T cell homeostasis
Shengbing Zang et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
Integrated genomic characterization of oesophageal carcinoma
Jihun Kim et al.
NATURE (2017)
PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas
Hezhe Lu et al.
NATURE (2017)
Whole-genome landscapes of major melanoma subtypes
Nicholas K. Hayward et al.
NATURE (2017)
Insertional mutagenesis identifies drivers of a novel oncogenic pathway in invasive lobular breast carcinoma
Sjors M. Kas et al.
NATURE GENETICS (2017)
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
Ahmet Zehir et al.
NATURE MEDICINE (2017)
SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression
P. Gonyo et al.
ONCOGENE (2017)
Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas
Francesco Abate et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors
Jiqiu Cheng et al.
NATURE COMMUNICATIONS (2017)
Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies
Emmet J. Jordan et al.
CANCER DISCOVERY (2017)
Small G protein Rac GTPases regulate the maintenance of glioblastoma stem-like cells in vitro and in vivo
Yun-Ju Lai et al.
ONCOTARGET (2017)
The Functional Impact of Alternative Splicing in Cancer
Hector Climente-Gonzalez et al.
CELL REPORTS (2017)
3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets
Jianjiong Gao et al.
GENOME MEDICINE (2017)
The Molecular Landscape of Recurrent and Metastatic Head and Neck Cancers Insights From a Precision Oncology Sequencing Platform
Luc G. T. Morris et al.
JAMA ONCOLOGY (2017)
A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia
Javier Robles-Valero et al.
CANCER CELL (2017)
Universal Patterns of Selection in Cancer and Somatic Tissues
Inigo Martincorena et al.
CELL (2017)
Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer
A. Gordon Robertson et al.
CELL (2017)
Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma
Anupama Reddy et al.
CELL (2017)
P-Rex1 and P-Rex2 RacGEFs and cancer
Nuthasuda Srijakotre et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2017)
Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening
E. Robert McDonald et al.
CELL (2017)
Defining a Cancer Dependency Map
Aviad Tsherniak et al.
CELL (2017)
TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells
Zoi Diamantopoulou et al.
CANCER CELL (2017)
Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma
Verline Justilien et al.
CANCER CELL (2017)
Variegated RHOA mutations in adult T-cell leukemia/lymphoma
Yasunobu Nagata et al.
BLOOD (2016)
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity
Matthew T. Chang et al.
NATURE BIOTECHNOLOGY (2016)
Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma
Rebecca L. Boddicker et al.
BLOOD (2016)
Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas
David Vallois et al.
BLOOD (2016)
Cancer-associated mutations in the protrusion targeting region of p190RhoGAP impact tumor cell migration
Fabien Biname et al.
JOURNAL OF CELL BIOLOGY (2016)
Comprehensive mutation profiling of mucinous gastric carcinoma
Hirofumi Rokutan et al.
JOURNAL OF PATHOLOGY (2016)
Landscape of somatic mutations in 560 breast cancer whole-genome sequences
Serena Nik-Zainal et al.
NATURE (2016)
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
Joshua D. Campbell et al.
NATURE GENETICS (2016)
Unsupervised detection of cancer driver mutations with parsimony-guided learning
Runjun D. Kumar et al.
NATURE GENETICS (2016)
Regulating Rho GTPases and their regulators
Richard G. Hodge et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
Characterization of Novel Molecular Mechanisms Favoring Rac1 Membrane Translocation
Antonio Castro-Castro et al.
PLOS ONE (2016)
Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma
Yonathan Lissanu Deribe et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Suppression of KRas-mutant cancer through the combined inhibition of KRAS with PLK1 and ROCK
Jieqiong Wang et al.
NATURE COMMUNICATIONS (2016)
A new role of the Rac-GAP β2-chimaerin in cell adhesion reveals opposite functions in breast cancer initiation and tumor progression
Victoria Casado-Medrano et al.
ONCOTARGET (2016)
Semaphorin-3F suppresses the stemness of colorectal cancer cells by inactivating Rac1
Jun Rao et al.
CANCER LETTERS (2015)
The Molecular Taxonomy of Primary Prostate Cancer
Adam Abeshouse et al.
CELL (2015)
Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer
Giovanni Ciriello et al.
CELL (2015)
Approaches of targeting Rho GTPases in cancer drug discovery
Yuan Lin et al.
EXPERT OPINION ON DRUG DISCOVERY (2015)
Whole genomes redefine the mutational landscape of pancreatic cancer
Nicola Waddell et al.
NATURE (2015)
Comprehensive genomic characterization of head and neck squamous cell carcinomas
Michael S. Lawrence et al.
NATURE (2015)
Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway
A. Hunter Shain et al.
NATURE GENETICS (2015)
Integrated molecular analysis of adult T cell leukemia/lymphoma
Keisuke Kataoka et al.
NATURE GENETICS (2015)
A role for Rac1 activity in malignant progression of sebaceous skin tumors
D. Frances et al.
ONCOGENE (2015)
RAC1 P29S regulates PD-L1 expression in melanoma
Ha Linh Vu et al.
PIGMENT CELL & MELANOMA RESEARCH (2015)
Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice
Inuk Zandvakili et al.
PLOS ONE (2015)
Mitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2
Marta E. Capala et al.
PLOS ONE (2015)
Genomic alterations in BCL2L1 and DLC1 contribute to drug sensitivity in gastric cancer
Hansoo Park et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation
Helen J. Whalley et al.
NATURE COMMUNICATIONS (2015)
Regulation and functional significance of CDC42 alternative splicing in ovarian cancer
Xiaolong He et al.
ONCOTARGET (2015)
Conditional deletion of nonmuscle myosin II-A in mouse tongue epithelium results in squamous cell carcinoma
Mary Anne Conti et al.
SCIENTIFIC REPORTS (2015)
Tiam1/Rac1 signals contribute to the proliferation and chemoresistance, but not motility, of chronic lymphocytic leukemia cells
Sebastian W. Hofbauer et al.
BLOOD (2014)
GAP-independent functions of DLC1 in metastasis
David Barras et al.
CANCER AND METASTASIS REVIEWS (2014)
The RhoGEF GEF-H1 Is Required for Oncogenic RAS Signaling via KSR-1
Jane Cullis et al.
CANCER CELL (2014)
CDC42 Inhibition Suppresses Progression of Incipient Intestinal Tumors
Ryotaro Sakamori et al.
CANCER RESEARCH (2014)
The RAC1 P29S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF
Ian R. Watson et al.
CANCER RESEARCH (2014)
Arhgef7 promotes activation of the Hippo pathway core kinase Lats
Emad Heidary Arash et al.
EMBO JOURNAL (2014)
PI3K Regulation of RAC1 Is Required for KRAS-Induced Pancreatic Tumorigenesis in Mice
Chia-Yen C. Wu et al.
GASTROENTEROLOGY (2014)
The RhoGAP ARHGAP19 controls cytokinesis and chromosome segregation in T lymphocytes
Muriel D. David et al.
JOURNAL OF CELL SCIENCE (2014)
RhoB Promotes Cancer Initiation by Protecting Keratinocytes from UVB-Induced Apoptosis but Limits Tumor Aggressiveness
Nicolas Meyer et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)
Comprehensive molecular characterization of gastric adenocarcinoma
Adam J. Bass et al.
NATURE (2014)
Comprehensive molecular characterization of urothelial bladder carcinoma
John N. Weinstein et al.
NATURE (2014)
Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma
Miwako Kakiuchi et al.
NATURE GENETICS (2014)
A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma
Hae Yong Yoo et al.
NATURE GENETICS (2014)
Somatic RHOA mutation in angioimmunoblastic T cell lymphoma
Mamiko Sakata-Yanagimoto et al.
NATURE GENETICS (2014)
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer
Kai Wang et al.
NATURE GENETICS (2014)
Crosstalk of Ras and Rho: activation of RhoA abates Kras-induced liver tumorigenesis in transgenic zebrafish models
T. W. Chew et al.
ONCOGENE (2014)
Downregulation of ROCK2 through Nanocomplex Sensitizes the Cytotoxic Effect of Temozolomide in U251 Glioma Cells
Xiaojun Wen et al.
PLOS ONE (2014)
RhoC Regulates Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma by Overexpressing IL-6 and Phosphorylation of STAT3
Mozaffarul Islam et al.
PLOS ONE (2014)
Arhgap36-dependent activation of Gli transcription factors
Paul G. Rack et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Direct in Vivo RNAi Screen Unveils Myosin IIa as a Tumor Suppressor of Squamous Cell Carcinomas
Daniel Schramek et al.
SCIENCE (2014)
RHOA inactivation enhances Wnt signalling and promotes colorectal cancer
Paulo Rodrigues et al.
NATURE COMMUNICATIONS (2014)
Somatic ERCC2 Mutations Correlate with Cisplatin Sensitivity in Muscle-Invasive Urothelial Carcinoma
Eliezer M. Van Allen et al.
CANCER DISCOVERY (2014)
Sema3C Promotes the Survival and Tumorigenicity of Glioma Stem Cells through Rac1 Activation
Jianghong Man et al.
CELL REPORTS (2014)
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies
Glenn S. Cowley et al.
SCIENTIFIC DATA (2014)
PAK signalling during the development and progression of cancer
Maria Radu et al.
NATURE REVIEWS CANCER (2014)
VAV3 mediates resistance to breast cancer endocrine therapy
Helena Aguilar et al.
BREAST CANCER RESEARCH (2014)
RNA-aptamers that modulate the RhoGEF activity of Tiam1
Bjoern Niebel et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2013)
Pak1 Kinase Links ErbB2 to β-Catenin in Transformation of Breast Epithelial Cells
Luis E. Arias-Romero et al.
CANCER RESEARCH (2013)
RAS and RHO Families of GTPases Directly Regulate Distinct Phosphoinositide 3-Kinase Isoforms
Ralph Fritsch et al.
CELL (2013)
A new signaling paradigm to control the prenylation and trafficking of small GTPases
Carol L. Williams
CELL CYCLE (2013)
ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation
Kevin B. Myant et al.
CELL STEM CELL (2013)
PAK1 Mediates Resistance to PI3K Inhibition in Lymphomas
Katherine Walsh et al.
CLINICAL CANCER RESEARCH (2013)
Pak and Rac GTPases promote oncogenic KIT-induced neoplasms
Holly Martin et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Constitutive Rac Activation Is Not Sufficient to Initiate Melanocyte Neoplasia but Accelerates Malignant Progression
Lucy E. Dalton et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)
Contributions of the RhoGEF activity of p210 BCR/ABL to disease progression
I. Tala et al.
LEUKEMIA (2013)
Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation
Guangwu Guo et al.
NATURE GENETICS (2013)
The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis
C. Zhou et al.
ONCOGENE (2013)
Tiam1 Transgenic Mice Display Increased Tumor Invasive and Metastatic Potential of Colorectal Cancer after 1,2-Dimethylhydrazine Treatment
Li-Na Yu et al.
PLOS ONE (2013)
XPLN is an endogenous inhibitor of mTORC2
Nidhi Khanna et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors
Xun Shang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Transforming mutations of RAC guanosine triphosphatases in human cancers
Masahito Kawazu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
RAC1P29S is a spontaneously activating cancer-associated GTPase
Matthew J. Davis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
The Rho Exchange Factors Vav2 and Vav3 Favor Skin Tumor Initiation and Promotion by Engaging Extracellular Signaling Loops
Mauricio Menacho-Marquez et al.
PLOS BIOLOGY (2013)
Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival
Kyung Hee Chang et al.
BLOOD (2012)
A Landscape of Driver Mutations in Melanoma
Eran Hodis et al.
CELL (2012)
Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy
Nicola Rath et al.
EMBO REPORTS (2012)
Recurrent R-spondin fusions in colon cancer
Somasekar Seshagiri et al.
NATURE (2012)
Comprehensive molecular portraits of human breast tumours
Daniel C. Koboldt et al.
NATURE (2012)
Melanoma genome sequencing reveals frequent PREX2 mutations
Michael F. Berger et al.
NATURE (2012)
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
Michael Krauthammer et al.
NATURE GENETICS (2012)
A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer
S. Rao et al.
ONCOGENE (2012)
The Role of Dlc1 Isoform 2 in K-Ras2G12D Induced Thymic Cancer
Mohammad Golam Sabbir et al.
PLOS ONE (2012)
RhoC Impacts the Metastatic Potential and Abundance of Breast Cancer Stem Cells
Devin T. Rosenthal et al.
PLOS ONE (2012)
The Rho Exchange Factors Vav2 and Vav3 Control a Lung Metastasis-Specific Transcriptional Program in Breast Cancer Cells
Carmen Citterio et al.
SCIENCE SIGNALING (2012)
Matrix Metalloproteinase Induction of Rac1b, a Key Effector of Lung Cancer Progression
Melody L. Stallings-Mann et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Rho GTPase regulation by miRNAs and covalent modifications
Ming Liu et al.
TRENDS IN CELL BIOLOGY (2012)
Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia
Benjamin Mizukawa et al.
BLOOD (2011)
Actomyosin-Mediated Cellular Tension Drives Increased Tissue Stiffness and β-Catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth
Michael S. Samuel et al.
CANCER CELL (2011)
Signaling circuitries controlling stem cell fate: to be or not to be
Ramiro Iglesias-Bartolome et al.
CURRENT OPINION IN CELL BIOLOGY (2011)
Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation
Antonio Castro-Castro et al.
EMBO JOURNAL (2011)
Copy number and targeted mutational analysis reveals novel somatic events in metastatic prostate tumors
Christiane M. Robbins et al.
GENOME RESEARCH (2011)
Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size
Abdelhafid Saci et al.
MOLECULAR CELL (2011)
K-Ras Mediated Murine Epidermal Tumorigenesis Is Dependent upon and Associated with Elevated Rac1 Activity
Michael S. Samuel et al.
PLOS ONE (2011)
Rac1 Targeting Suppresses Human Non-Small Cell Lung Adenocarcinoma Cancer Stem Cell Activity
Shailaja Akunuru et al.
PLOS ONE (2011)
The Mutational Landscape of Head and Neck Squamous Cell Carcinoma
Nicolas Stransky et al.
SCIENCE (2011)
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis
Colin R. Lindsay et al.
NATURE COMMUNICATIONS (2011)
RAS oncogenes: weaving a tumorigenic web
Yuliya Pylayeva-Gupta et al.
NATURE REVIEWS CANCER (2011)
Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo
Amitava Sengupta et al.
BLOOD (2010)
Tiam1-Rac Signaling Counteracts Eg5 during Bipolar Spindle Assembly to Facilitate Chromosome Congression
Simon A. Woodcock et al.
CURRENT BIOLOGY (2010)
The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells
Vincent Sauzeau et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
The role of rho protein signaling in hypertension
Gervaise Loirand et al.
NATURE REVIEWS CARDIOLOGY (2010)
Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo
Z. Wang et al.
ONCOGENE (2010)
Activating ROCK1 somatic mutations in human cancer
P. A. Lochhead et al.
ONCOGENE (2010)
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
Dominico Vigil et al.
NATURE REVIEWS CANCER (2010)
P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis
Peter R. McHenry et al.
BREAST CANCER RESEARCH (2010)
Aptamer-Derived Peptides as Potent Inhibitors of the Oncogenic RhoGEF Tgat
Nathalie Bouquier et al.
CHEMISTRY & BIOLOGY (2009)
The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in ApcMin/+ mice
Yoshihiro Kawasaki et al.
EMBO REPORTS (2009)
Tiam1-deficiency impairs mammary tumor formation in MMTV-c-neu but not in MMTV-c-myc mice
K. Strumane et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2009)
Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a
Barry Fine et al.
SCIENCE (2009)
Haploinsufficiency for p190B RhoGAP inhibits MMTV-Neu tumor progression
Brandy M. Heckman-Stoddard et al.
BREAST CANCER RESEARCH (2009)
Continuous cell injury promotes hepatic tumorigenesis in Cdc42-deficient mouse liver
Jolanda Van Hengel et al.
GASTROENTEROLOGY (2008)
Scaffolding function of PAK in the PDK1-Akt pathway
Maiko Higuchi et al.
NATURE CELL BIOLOGY (2008)
Requirement for Rac1 in a K-ras-induced lung cancer in the mouse
Joseph L. Kissil et al.
CANCER RESEARCH (2007)
GEFs and GAPs: Critical elements in the control of small G proteins
Johannes L. Bos et al.
CELL (2007)
GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo
Xose R. Bustelo et al.
BIOESSAYS (2007)
PAK1 hyperactivation is sufficient for mammary gland tumor formation
R-A Wang et al.
ONCOGENE (2006)
Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity
LS Lyons et al.
MOLECULAR ENDOCRINOLOGY (2006)
Interactions of UNC-34 enabled with Rac GTPases and the NIK kinase MIG-15 in Caenorhabditis elegans axon pathfinding and neuronal migration
MA Shakir et al.
GENETICS (2006)
The Rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development
A Malliri et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Rho, Rac, Pak and angiogenesis: old roles and newly identified responsibilities in endothelial cells
BH Fryer et al.
CANCER LETTERS (2005)
Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1
EH van der Horst et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Rho GTPases, dendritic structure, and mental retardation
SE Newey et al.
JOURNAL OF NEUROBIOLOGY (2005)
The role of the Rho GTPases in neuronal development
EE Govek et al.
GENES & DEVELOPMENT (2005)
RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis
A Hakem et al.
GENES & DEVELOPMENT (2005)
RAS and RHO GTPases in G1-phase cell-cycle regulation
ML Coleman et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)
The RacGEF Tiam1 inhibits migration and invasion of metastatic melanoma via a novel adhesive mechanism
K Uhlenbrock et al.
JOURNAL OF CELL SCIENCE (2004)
Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation
A Singh et al.
ONCOGENE (2004)
An alternative transcript derived from the trio locus encodes a guanosine nucleotide exchange factor with mouse cell-transforming potential
N Yoshizuka et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Understanding Rho/Rac biology in T-cells using animal models
XR Bustelo
BIOESSAYS (2002)
Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours
A Malliri et al.
NATURE (2002)
RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells
AX Liu et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Ras and Rho GTPases: A family reunion
D Bar-Sagi et al.
CELL (2000)
Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b
A Schnelzer et al.
ONCOGENE (2000)
Major transcript variants of VAV3, a new member of the VAV family of guanine nucleotide exchange factors
T Trenkle et al.
GENE (2000)
A guanine nucleotide exchange factor-independent function of Vav1 in transcriptional activation
MR Kuhne et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)