Journal
RSC ADVANCES
Volume 6, Issue 27, Pages 22673-22678Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra27625j
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Funding
- National Natural Science Foundation of China [91333203]
- Natural Science Foundation of Zhejiang province [LY14E020006]
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By integrating thin-layer molybdenum disulfide (MoS2) and graphene through a hydrothermal process and an ultrasonic method, a label-free, amplification-free and ultrasensitive circulating tumor DNA electrochemical sensor was made. Compared with other methods, this preparation process was simpler and the electrochemical properties were enhanced. Using a differential pulse voltammetry test, this sensor can detect trace amounts of DNA in the range from 10(-16) M to 10(-13) M. Compared with other methods that are used to detect the same circulating tumor DNA, this sensor has an obvious advantage in sensitivity, cost and simplicity because it removes the need for labelling processes and amplifiers.
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