Journal
CLINICAL OPHTHALMOLOGY
Volume 10, Issue -, Pages 321-330Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OPTH.S83467
Keywords
Fuchs endothelial corneal dystrophy; corneal endothelial cell; corneal transplantation; Descemet's stripping automated endothelial keratoplasty; Descemet's membrane endothelial keratoplasty; endothelial keratoplasty
Categories
Ask authors/readers for more resources
Fuchs endothelial conical dystrophy (FECD) is the most coinmon corneal dystrophy and frequently results in vision loss. Hallmarks of the disease include loss of corneal endothelial cells and formation of excrescences of Descemet's membrane. Later stages involve all layers of the cornea. Impairment of endothelial barrier and pump function and cell death from oxidative and unfolded protein stress contribute to disease progression. The genetic basis of FECD includes numerous genes and chromosomal loci, although alterations in the transcription factor 4 gene are associated with the majority of cases. Definitive treatment of FECD is corneal transplantation. In this paper, we highlight advances that have been made in understanding FECD's clinical features, pathophysiology, and genetics. We also discuss recent advances in endothelial keratoplasty and potential future treatments.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available