Journal
RSC ADVANCES
Volume 6, Issue 27, Pages 22575-22585Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ra00347h
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Funding
- National Natural Science Foundation of China [81230030, 81571729]
- State Key Laboratory of Oncogenes and Related Genes [90-15-03]
- Med-Engineering Crossing Foundation of SJTU [YG2012MS15]
- Xinglin scholar training program of Shanghai University of Traditional Chinese Medicine
- 315 talent program of Putuo District and Construct Program of the Key Discipline of State Administration of Traditional Chinese Medicine of People's Republic of China
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Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles with high stability in physiological conditions have great potential for T-1-weighted MRI. In the current study, we developed a procedure for ultra-large-scale production of USPIOs (1.5 kg per batch) for T-1-weighted MRI. The USPIOs were coated with poly(acrylic acid) (PAA@USPIOs). They were uniform in size (similar to 4.5 nm) and very stable in physiological conditions even after being sterilized in an autoclave. Due to their small size, the PAA@USPIOs demonstrated good T-1 MRI contrast effect and could be used for both first-pass and steady-state magnetic resonance angiography (MRA). After being injected with PAA@USPIOs at the dose of 135 mu mol Fe per kg, the head-neck vasculatures and abdominal artery of rabbits and the coronary artery of pigs could be clearly visualized by T-1-weighted MRI. Moreover, PAA@USPIOs were highly tolerable by animals. Our study indicated that the procedure developed in this study has great promise for large-scale production of USPIOs for T-1-weighted MRI for future clinical applications.
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