Journal
GENOME BIOLOGY
Volume 17, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s13059-016-0918-z
Keywords
aDNA; Bioinformatics; Authentication; aDNA analysis; Genome reconstruction
Funding
- Max Planck Society
- Deutsche Forschungsgemeinschaft
- Open Access Publishing of the University of Tubingen
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Background: The automated reconstruction of genome sequences in ancient genome analysis is a multifaceted process. Results: Here we introduce EAGER, a time-efficient pipeline, which greatly simplifies the analysis of large-scale genomic data sets. EAGER provides features to preprocess, map, authenticate, and assess the quality of ancient DNA samples. Additionally, EAGER comprises tools to genotype samples to discover, filter, and analyze variants. Conclusions: EAGER encompasses both state-of-the-art tools for each step as well as new complementary tools tailored for ancient DNA data within a single integrated solution in an easily accessible format.
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