Journal
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
Volume 26, Issue 1, Pages 13-24Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/hmbci-2015-0041
Keywords
diabetes; exercise; mass spectrometry; metabolism; muscle contraction; myokines; obesity; proteomics; secretome
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Funding
- Novo Nordisk Foundation Center for Protein Research [NNF14CC0001]
- Federation of European Biochemical Societies (FEBS)
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Skeletal muscle is the largest tissues in the human body and is considered the primary target for insulin-stimulated glucose disposal. In skeletal muscle, binding of the insulin to insulin receptor (IR) initiates a signaling cascade that results in the translocation of the insulin-sensitive glucose transporter protein 4 (GLUT4) to the plasma membrane which leads to facilitated diffusion of glucose into the cell. Understanding the precise signaling events guiding insulin-stimulated glucose uptake is pivotal, because impairment in these signaling events leads to development of insulin resistance and type 2 diabetes. This review summarizes current understanding of insulin signaling pathways mediating glucose uptake in healthy and insulin-resistant skeletal muscle.
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