Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 500, Issue 1, Pages 59-64Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2017.06.094
Keywords
Mitochondrial dynamics; Stem cell; Differentiation; Notch signalling; Wnt signalling; YAP/TAZ signalling
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Funding
- JSPS
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [17K17758] Funding Source: KAKEN
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Cells differentiate into specific and functional lineages to build up tissues. It has been shown in several tissues that mitochondrial morphology, levels of mitochondria-shaping proteins, and mitochondrial functions change upon differentiation. In this review, we highlight the significance of mitochondrial dynamics and functions in tissue development, cell differentiation, and reprogramming processes. Signalling cascades are critical for tissue stem cell maintenance and cell fate determination, and growing evidence demonstrates mitochondria could act as a centre of intra and extracellular signals to coordinate signalling pathways, such as Notch, Wnt, and YAP/TAZ signalling. Just an organelle, however, emerges as a master regulator of cell differentiation, and can be a target to manipulate cell fates. (C) 2017 Elsevier Inc. All rights reserved.
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