Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 497, Issue 3, Pages 897-902Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2018.02.166
Keywords
Acute gouty arthritis; IL-17; gamma delta T cell; IL-1 beta
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Funding
- National Health and Family Planning Commission of the People's Republic of China, China [W2015CAE016]
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Acute gouty arthritis (AGA) is one of the most common forms of auto-inflammatory arthritis. IL-17 is a key proinflammatory cytokine which has been implicated in several autoimmune diseases. However, to date little is known about the role of IL-17 in AGA. In the present study, we show that serum IL-17 levels are significantly elevated in AGA patients early in the onset of symptoms of gout, and decrease gradually as symptoms diminish. Correlation analysis indicated that IL-17 expression is not only positively correlated with disease activity, but is also correlated with serum levels of IL-1 beta which plays a critical role in the differentiation of IL-17(-)gamma delta T cells into IL-17(+)gamma delta T cells. Flow cytometry analysis indicated that gamma delta T cells are a major source of IL-17 production during the early onset of AGA. We therefore identify IL-17 as a potential novel biomarker for AGA and suggest that targeting the gamma delta T cell/IL-17 immune axis is a potential strategy for treatment of acute flares of AGA. (C) 2018 The Authors. Published by Elsevier Inc.
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