Journal
FEMS YEAST RESEARCH
Volume 15, Issue 4, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/femsyr/fov027
Keywords
fungal pathogenesis; mitochondria; Candida albicans
Funding
- Georgetown University Medical Center Biomedical Graduate Research Organization
- NIH-NIAID [AI090290]
- Australian National Health and Medical Research Council [APP1023973]
- Australian Research Council [DP130100578]
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The mitochondrion plays wide-ranging roles in eukaryotic cell physiology. In pathogenic fungi, this central metabolic organelle mediates a range of functions related to disease, from fitness of the pathogen to developmental and morphogenetic transitions to antifungal drug susceptibility. In this review, we present the latest findings in this area. We focus on likely mechanisms of mitochondrial impact on fungal virulence pathways through metabolism and stress responses, but also potentially via control over signaling pathways. We highlight fungal mitochondrial proteins that lack human homologs, and which could be inhibited as a novel approach to antifungal drug strategy.
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