T cell receptor signalling in the control of regulatory T cell differentiation and function

Regulatory Tcells (T-Reg cells), a specialized T cell lineage, have a pivotal function in the control of self tolerance and inflammatory responses. Recent studies have revealed a discrete mode of T cell receptor (TCR) signalling that regulates T-Reg cell differentiation, maintenance and function and that affects gene expression, metabolism, cell adhesion and migration of these cells. Here, we discuss the emerging understanding of TCR-guided differentiation of T-Reg cells in the context of their function in health and disease.