Journal
FEBS LETTERS
Volume 589, Issue 15, Pages 1728-1734Publisher
WILEY
DOI: 10.1016/j.febslet.2015.05.054
Keywords
Peripheral serotonin; Pancreatic beta cell; Hepatocyte; Adipocyte; Diabetes
Funding
- Emmy Noether Grant from German Research Foundation (DFG) [Su 820/1-1]
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Metabolic homeostasis in the organism is assured both by the nervous system and by hormones; Among a plethora of hormonesTeg-ulating metabolism, serotonin presents a number of unique features. Unlike classical hormones serotonin is produced in different anatomical locations. In brain it acts as a neurotransmitter and in the periphery it can act as a hormone, auto- and/or paracrine factor, or intracellular signaling molecule. Serotonin does not cross the blood-brain barrier; therefore the two major pools of this bioamine remain separated. Although 95% of serotonin is produced in the periphery, its functions have been ignored until recently. Here we review the impact of the peripheral serotonin on the regulation of function of the organs involved in glucose and lipid homeostasis. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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