Journal
FEBS LETTERS
Volume 589, Issue 24, Pages 3702-3713Publisher
WILEY
DOI: 10.1016/j.febslet.2015.10.021
Keywords
Mitochondria; Parkinson's disease; Dopamine; Bioenergetics; Neurodegeneration
Funding
- Betty Brown's Family
- Joan and David Traitel Family Trust
- NIH [1RO1NS091902]
- Larry L. Hillblom Foundation Fellowship
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Mitochondria are undoubtedly changed in Parkinson's disease (PD), and mitochondrial functions are disrupted in genetic and pharmacologic models of PD. However, many of these changes might not truly drive neurodegeneration. PD is defined by the particular susceptibility of nigrostriatal dopamine (DA) neurons, but little is understood about the mitochondria in these cells. Here, we critically review the evidence that mitochondrial stressors cause PD. We then consider how changes in the intrinsic function of mitochondria and in their mass, distribution, and dynamics might synergize with an increased need for mitochondria and produce PD, and the importance of understanding how mitochondria contribute to its pathogenesis. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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