Journal
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
Volume 32, Issue 5, Pages 657-668Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.beem.2018.05.005
Keywords
bone turnover; genetics; Paget's disease; SQSTM1; zoledronate
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Paget's disease of bone is a focal disorder of bone remodelling that progresses slowly and leads to changes in the shape and size of affected bones and to skeletal, articular and vascular complications. In some parts of the world it is the second most common bone disorder after osteoporosis though in recent years its prevalence and severity appear to decrease. The disease is easily diagnosed and effectively treated but its pathogenesis remains incompletely understood. (C) 2018 Elsevier Ltd. All rights reserved.
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