Journal
FEBS LETTERS
Volume 589, Issue 17, Pages 2248-2256Publisher
WILEY
DOI: 10.1016/j.febslet.2015.06.037
Keywords
ILT4; B7-H3; PI3K/AKT/mTOR signalling; Non-small cell lung cancer
Funding
- National Natural Science Foundation of China [81372334]
- Department of Science and Technology of Shandong Province [2013GSF12107]
- Project of Jinan Youth Team for Technological Innovation [2010-1]
- Department of Science and Technology of Jinan City [201201061]
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Immunoglobulin-like transcript (ILT) 4 is critical for the inhibitory function of certain immune cells. We previously demonstrated that ILT4 is over-expressed in human non-small cell lung cancer (NSCLC) cells and is involved in tumour evasion via an unknown mechanism. In this report, we demonstrate that ILT4 increases the expression of the co-inhibitory molecule B7-H3 through PI3K/AKT/mTOR signalling. In primary human NSCLC tissues, a significant positive relationship is observed between ILT4 and B7-H3 expression. ILT4/B7-H3 co-expression is significantly associated with a reduction in T infiltrating lymphoid cells and lower overall survival. In summary, ILT4 increases B7-H3 expression and ILT4/B7-H3 co-expression may be involved in NSCLC progression. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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