4.5 Review

Progress in copper-catalyzed trifluoromethylation

Journal

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 14, Issue -, Pages 155-181

Publisher

BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.14.11

Keywords

copper; fluorine; trifluoromethylation

Funding

  1. National Natural Science Foundation of China [81473085]
  2. Major Project of Shandong [2015ZDXX0301A03]
  3. Natural Science Foundation of Shandong [2013ZRE27169]

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The introduction of trifluoromethyl groups into organic molecules has attracted great attention in the past five years. In this review, we describe the recent efforts in the development of trifluoromethylation via copper catalysis using nucleophilic, electrophilic or radical trifluoromethylation reagents.

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