Journal
FEBS LETTERS
Volume 590, Issue 1, Pages 185-192Publisher
ELSEVIER SCIENCE BV
DOI: 10.1002/1873-3468.12024
Keywords
cell-to-cell communication; exosomes; microRNA; osteoblast differentiation
Funding
- National Natural Science Foundation of China [81371909]
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Mineralizing osteoblasts (MOBs) can release exosomes, although the functional significance remains unclear. In the present study, we demonstrate that exosomes derived from mineralizing pre-osteoblast MC3T3-E1 cells can promote bone marrow stromal cell (ST2) differentiation to osteoblasts. We reveal that MOB-derived exosomes significantly influence miRNA profiles in recipient ST2 cells, and these changes tend to activate the Wnt signaling pathway by inhibiting Axin1 expression and increasing -catenin expression. We also suggest that MOB derived-exosomes partly induce the variation in miRNA expression in recipient ST2 cells by exosomal miRNA transfer. These findings suggest an exosome-mediated mode of cell-to-cell communication in the osteogenic microenvironment, and also indicate the potential of MOB exosomes in bone tissue engineering.
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