Journal
FEBS LETTERS
Volume 589, Issue 24, Pages 3795-3806Publisher
WILEY
DOI: 10.1016/j.febslet.2015.10.032
Keywords
LIM kinase 1; LIM kinase 2; Neuronal function; Neurodevelopmental disease; Neurodegenerative disease
Funding
- Region Centre
- Ligue Contre le Cancer
- Centre National de la Recherche Scientifique
- Institut National de la Sante et de la Recherche Medicale
- Universite Francois Rabelais de Tours
- Ministere de l'Enseignement Superieur et de la Recherche
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LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) regulate actin dynamics by phosphorylating cofilin. In this review, we outline studies that have shown an involvement of LIMKs in neuronal function and we detail some of the pathways and molecular mechanisms involving LIMKs in neurodevelopment and synaptic plasticity. We also review the involvement of LIMKs in neuronal diseases and emphasize the differences in the regulation of LIMKs expression and mode of action. We finally present the existence of a cofilin-independent pathway also involved in neuronal function. A better understanding of the differences between both LIMKs and of the precise molecular mechanisms involved in their mode of action and regulation is now required to improve our understanding of the physiopathology of the neuronal diseases associated with LIMKs. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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