Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 353, Issue -, Pages 168-175Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2018.07.005
Keywords
Anxiolytic-like behavior; Brain stimulation; Elevated plus-maze; Infralimbic cortex; Medial prefrontal cortex; Multiunit recording
Categories
Funding
- Japan Society for the Promotion of Science (JSPS) [KAKENHI 17H02121]
- [267534]
Ask authors/readers for more resources
Fear and anxiety affect the activities of daily living and require concerted management, such as coping strategies, to preserve quality of life. The infralimbic (IL) and prelimbic (PL) medial prefrontal cortices have been implicated in the regulation of fear- and anxiety-like behavior, but their roles in overcoming fear- and anxiety like behavior remain unknown. We investigated the anxiolytic-like effects of electrical stimulation of the IL and PL cortices in rats during the elevated plus-maze test. IL stimulation led to a significantly higher percentage of time spent and entries in the open arms, whereas PL stimulation did not have any significant behavioral effects. Subsequently, we recorded multiunit activity from the IL and PL cortices in rats using a wireless telemetry device, to determine whether activation of the IL occurs when rats enter the open arms in the elevated plus-maze test. The firing rate of IL neurons increased 1-3 s prior to entry from the closed arm to the open arm, whereas there were no corresponding changes in the firing rate of PL neurons. Taken together, the present findings suggest that the IL plays a key role in exerting active action to overcome anxiety-like behavior.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available