Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 340, Issue -, Pages 23-28Publisher
ELSEVIER
DOI: 10.1016/j.bbr.2016.05.055
Keywords
Traumatic brain injury; Subdural hematoma; Decompressive craniotomy; Ischemic/reperfusional brain injury; Therapeutic hypothermia
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Funding
- NINDS [R01 NS 042133]
- Miami Project to Cure Paralysis
- JSPS KAKENHI [26293386]
- JSPS [16K15768]
- Grants-in-Aid for Scientific Research [26293386, 16K15768] Funding Source: KAKEN
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The prognosis for patients with traumatic brain injury (TBI) with subdural hematoma (SDH) remains poor. In accordance with an increasing elderly population, the incidence of geriatric TBI with SDH is rising. An important contributor to the neurological injury associated with SDH is the ischemic damage which is caused by raised intracranial pressure (ICP) producing impaired cerebral perfusion. To control intracranial hypertension, the current management consists of hematoma evacuation with or without decompressive craniotomy. This removal of the SDH results in the immediate reversal of global ischemia accompanied by an abrupt reduction of mass lesion and an ensuing reperfusion injury. Experimental models can play a critical role in improving our understanding of the underlying pathophysiology and in exploring potential treatments for patients with SDH. In this review, we describe the epidemiology, pathophysiology and clinical background of SDH. (C) 2016 Elsevier B.V. All rights reserved.
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