Journal
FEBS LETTERS
Volume 589, Issue 19, Pages 2859-2865Publisher
WILEY
DOI: 10.1016/j.febslet.2015.08.004
Keywords
Regulated in development and DNA damage response 1; CREB activation; Protein kinase A; Mitogen- and stress-activated protein kinase 1; Cyclooxygenase-2
Funding
- National Research Foundation of Korea (NRF) - Korea Government (MSIP) [2013M3A9B6046563]
- National Research Foundation of Korea [2013M3A9B6046563] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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REDD1 is induced by various cellular stresses; however, its expression in response to lipopolysaccharide (LPS) has not been clearly elucidated in immune cells. LPS stimulated CREB-dependent and NF-kappa B-independent REDD1 expression in macrophages. Early increases in CREB phosphorylation and REDD1 expression at 8 h following LPS treatment were blocked by inhibition of p38MAPK and mitogen- and stress-activated protein kinase 1 (MSK1), but not PICA. However, delayed CREB-mediated REDD1 expression at 16 h was suppressed by inhibition of cyclooxygenase-2 (COX-2) and PICA. It indicates that LPS induces REDD1 expression by two distinct CREB-mediated mechanisms, the early p38MAPK/MSK1 and the delayed COX-2/PGE(2)/PKA pathways. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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