Journal
FEBS LETTERS
Volume 589, Issue 20, Pages 3189-3196Publisher
WILEY-BLACKWELL
DOI: 10.1016/j.febslet.2015.08.046
Keywords
CXCR2; miRNA-22-3p; MALAT1; Endothelial cells; ox-LDL
Funding
- National Natural Science Foundation of China [81170125, 81270209]
- Doctoral Innovation Fund Projects from Shanghai JiaoTong University School of Medicine [BXJ201325]
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CXCR2 plays a key role in protecting the integrity of the endothelium. Emerging evidence has demonstrated that the long ncRNAs (IncRNA) Human metastasis associated lung adenocarcinoma transcript 1 (MALAT1) participates in the regulation of the pathophysiological processes. However, whether there is crosstalk between CXCR2 and MALAT1 remains unknown. In this study, we demonstrated that MALAT1 was upregulated in patients with unstable angina. MALAT1 silencing significantly downregulated the expression of the miR-22-3p target gene CXCR2 via reversing the effect of the miR-22-3p, resulting in the aggravation of Oxidized low-density lipoprotein (ox-LDL)-induced endothelial injury; this process was associated with the AICT pathway. Thus, MALAT1 protects the endothelium from ox-LDL-induced endothelial dysfunction partly through competing with miR-22-3p for endogenous RNA. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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