Journal
FEBS LETTERS
Volume 589, Issue 11, Pages 1234-1239Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2015.04.006
Keywords
ER exit site; COPII; Sec24; Lst1; UPR; Endoplasmic reticulum
Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Naito Foundation
- Kurata Memorial Hitachi Science and Technology Foundation
- Noda Institute for Scientific Research
- Grants-in-Aid for Scientific Research [25440079, 26840031, 26102509] Funding Source: KAKEN
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COPII vesicles are formed at specific subdomains of the ER, termed ER exit sites (ERESs). Depending on the cell type, ERESs number from a few to several hundred per cell. However, whether these ERESs are functionally and compositionally identical at the cellular level remains unclear. Our live cell-imaging analysis in Saccharomyces cerevisiae revealed that the isoforms of cargo-adaptor subunits are unequally distributed to each ERES at steady state, whereas this distribution is altered in response to UPR activation. These results suggest that in S. cerevisiae cargo loading to ERES is dynamically controlled in response to environmental changes. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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