Journal
FEBS LETTERS
Volume 589, Issue 10, Pages 1164-1170Publisher
WILEY
DOI: 10.1016/j.febslet.2015.03.018
Keywords
Pannexin 1; Endothelium; Saphenous artery; Knockout mice; EDHF; Endothelium-derived hyperpolarization; ATP; Pannexins
Funding
- Russian Science Foundation [14-15-00704]
- Russian Science Foundation [14-15-00704] Funding Source: Russian Science Foundation
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Pannexin 1 (Panx1) is involved in endothelium-dependent vasodilation in large arteries, but the exact mechanistic role remains poorly understood. We hypothesized that Panx1 facilitates large vessel relaxations regulating endothelium-derived hyperpolarization (EDH)-like mechanisms. The EDH-like component of acetylcholine-induced relaxation of saphenous arteries studied in isometric myograph after inhibition of NO-synthase and cyclooxygenase was significantly impaired in mice with genetically ablated Panx1 (KO) relative to that in the wild type (WT) mice. Application of P1-receptor antagonist and apyrase significantly reduced this component in WT, but not in KO mice, indicating participation of ATP released via Panx1 in the EDH-like relaxation. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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