4.3 Article

Recent Developments in Microfluidic Chip for in vitro Cell-based Research

Journal

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
Volume 44, Issue 4, Pages 522-531

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/S1872-2040(16)60919-2

Keywords

Microfluidic chip; Cell culture; Microenvironment; Single cell; Organ-on-a-chip; Chip-mass spectrometry; Cell analysis; Review

Funding

  1. National Natural Science Foundation of China [81373373, 21227006, 21435002]
  2. China Equipment and Education Resources System [CERS-1-75]

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Microfluidic technology has become a powerful tool in cell-based research due to its inherent advantages. The research progress of cell culture on chips, simulation and manipulation of cell microenvironment on chips, single cell analysis on chips, organ-on-a-chip, and chip-mass spectrometry was introduced in this review. The prospect of microfluidic technology in cell-based researches was discussed to give some insights for researchers who were interested in developing microfluidic platforms for cell-based research.

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