Journal
FEBS LETTERS
Volume 589, Issue 24, Pages 4079-4087Publisher
WILEY
DOI: 10.1016/j.febslet.2015.11.024
Keywords
miR-190a; Long non-coding RNA; Translation regulatory long non-coding RNA; Hepatoma; Epithelial-to-mesenchymal transition
Funding
- National High-Tech Research and Development Program of China [2015AA020950]
- National Natural Science Foundation of China [31271382, 81201586]
- Fundamental Research Funds for the Central Universities [YS1407]
- open project of State Key Laboratory of Molecular Oncology [SKL-KF-2015-05]
- Beijing Higher Education Young Elite Teacher Project [YETP0521]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT13045]
- Innovation and Promotion Project of Beijing University of Chemical Technology
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treRNA is a long non-coding RNA (lncRNA) involved in cancer progression. In this study, we show that miR-190a can silence treRNA post-transcriptionally. Suppression of treRNA by miR-190a led to significant changes of mesenchymal-epithelial transition markers and impaired migration and invasion capability of hepatoma cells. TCGA data indicated that miR-190a exhibited lower expression in hepatoma tissues, especially from patients with vascular tumor invasion, compared to normal tissues. Our results reveal the involvement of miR-190a-treRNA axis in hepatoma progression and shed light on lncRNA-based cancer therapies for hepatoma patients at high risk of metastasis. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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