Journal
FEBS LETTERS
Volume 589, Issue 18, Pages 2424-2428Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2015.07.005
Keywords
RNA-protein complex; Kissing loop interaction; RNP nano-object
Funding
- Japan Society for the Promotion of Science [23221011, 23119005]
- Grants-in-Aid for Scientific Research [23221011] Funding Source: KAKEN
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Multifunctional molecular complexes are valuable tools with a variety of applications. We have developed an RNA-protein complex (RNP) containing three different proteins attached to the tips of a triangular RNA scaffold. We designed and constructed three RNA strands that specifically bind a ribosomal protein, L7Ae, and that autonomously form a single triangular RNP via RNA kissing loop (KL) interactions. This RNP-based approach can be used as an alternative tool to produce unique, multifunctional molecules with customized dimensions, functions, and targets. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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